VOLUME IMAGING TO INTERROGATE CANCER CELL-TUMOR MICROENVIRONMENT INTERACTIONS IN SPACE AND TIME

Volume imaging visualizes the three-dimensional accessories (3D) complexity of tumors to unravel the dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor microenvironment (TME).Tissue clearing and intravital microscopy (IVM) constitute rapidly progressing technologies to study the architectural context of such interac

A simplicial statistical model of multimodal functions is used to construct a global optimization algorithm.The search for the global minimum in the multidimensional space is reduced to the search over the edges of simplices covering the feasible region combined with the refinement of the cover.The refinement is performed by subdivision Sweater of